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PubMed · 17124079

Primary cutaneous T-cell lymphomas.

Steven T Rosen·Christiane Querfeld
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Abstract

Primary cutaneous T-cell lymphomas (CTCLs) encompass a clinically and biologically heterogeneous group of non-Hodgkin lymphomas (NHLs) defined by clonal proliferation of skin-homing malignant T lymphocytes and natural killer cells. They account for up to 75% to 80% of all cutaneous lymphomas. The current WHO-EORTC classification of cutaneous lymphomas with primary cutaneous manifestations lists 13 entities. The most common subtypes-mycosis fungoides, Sézary syndrome, primary cutaneous anaplastic large cell lymphoma, and lymphomatoid papulosis-which represent approximately 95% of CTCLs, will be discussed in the following review. Each entity has unique biological characteristics and clinical course. Topical and/or systemic therapies are employed based on the stage of the disease and the tempo of progression.

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Clone CellsHumansKiller Cells, NaturalLymphoma, T-Cell, CutaneousT-LymphocytesJournal ArticleReview

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BibTeXRIS

Steven T Rosen, Christiane Querfeld. 2006. Primary cutaneous T-cell lymphomas.. https://doi.org/10.1182/asheducation-2006.1.323

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