Re-evaluating cell-cycle regulation by E2Fs.

Benjamin D Rowland; René Bernards

doi:10.1016/j.cell.2006.11.019

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Re-evaluating cell-cycle regulation by E2Fs.

Benjamin D Rowland·René Bernards

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Abstract

Activation of E2F transcription factors is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication. However, this textbook view of E2Fs is increasingly under challenge. Here we discuss an alternative model for how E2Fs may work.

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Animals Cell Cycle E2F Transcription Factors Models, Genetic Protein Structure, Tertiary Repressor Proteins Transcriptional Activation Journal Article

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Benjamin D Rowland, René Bernards. 2006-12-01. Re-evaluating cell-cycle regulation by E2Fs.. https://doi.org/10.1016/j.cell.2006.11.019

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