Dynamics of single-cell gene expression.

Diane Longo; Jeff Hasty

doi:10.1038/msb4100110

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Dynamics of single-cell gene expression.

Diane Longo·Jeff Hasty

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Abstract

Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for a population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing biological processes in which cellular heterogeneity plays a key role. A unifying theme of many recent studies has been a focus on the development and utilization of single-cell experimental techniques that are capable of probing key biological phenomena in individual living cells. Recently, novel information about gene expression dynamics has been obtained from single-cell experiments that draw upon the unique capabilities of fluorescent reporter proteins.

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Animals Bacillus subtilis Cells Escherichia coli Gene Expression Regulation Microfluidics Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.Review

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Diane Longo, Jeff Hasty. 2006-11-28. Dynamics of single-cell gene expression.. https://doi.org/10.1038/msb4100110

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