Solid-phase total synthesis and structure proof of callipeltin B.

Ravi Krishnamoorthy; Leslie D Vazquez-Serrano; Jeffrey A Turk; Jennifer A Kowalski; Alan G Benson; Nneka T Breaux; Mark A Lipton

doi:10.1021/ja0666250

PubMed · 17132003

Solid-phase total synthesis and structure proof of callipeltin B.

Ravi Krishnamoorthy·Leslie D Vazquez-Serrano·Jeffrey A Turk·Jennifer A Kowalski·Alan G Benson·Nneka T Breaux·Mark A Lipton

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Abstract

The cytotoxic, cyclic heptadepsipeptide, natural product callipeltin B was synthesized on a solid-phase support in 15% overall yield. Comparison of the 1H NMR spectra of three synthetic isomers with those of callipeltin B confirmed the configurational reassignment of its threonine residues as d-allothreonine and the assignment of the configuration of its beta-methoxytyrosine residue as (2R,3R).

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Animals Depsipeptides Peptides, Cyclic Porifera Protein Conformation Journal Article Research Support, N.I.H., Extramural

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Ravi Krishnamoorthy, Leslie D Vazquez-Serrano, Jeffrey A Turk, Jennifer A Kowalski, Alan G Benson, Nneka T Breaux, Mark A Lipton. 2006-12-06. Solid-phase total synthesis and structure proof of callipeltin B.. https://doi.org/10.1021/ja0666250

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