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PubMed · 17137775

Transforming growth factor-beta: innately bipolar.

Sharon M Wahl
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Abstract

Widely heralded for depressing ongoing immune responses, renewed interest in the proficiency by which transforming growth factor beta (TGF-beta) not only engages but also might drive an over-reactive innate response highlights its bipolar nature. Although coordination of the development and function of Treg, in addition to direct inhibition of cellular activation, are prominent pathways by which TGF-beta controls adaptive immunity, paradoxically TGF-beta appears instrumental in initiation of host responses to invasion through recruitment and activation of immune cells and persuasion of Th17 lineage commitment. Nevertheless, true to its manic-depressive behavior, new evidence links TGF-beta with depression of innate cells, including NK cells, and by way of a potential bridge between mast cells and Treg. Disruption of the tenuous balance between these opposing actions of TGF-beta underlies immunopathogenicity.

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AnimalsCD4-Positive T-LymphocytesCell LineageHumansImmunity, InnateInflammationTransforming Growth Factor betaJournal ArticleResearch Support, N.I.H., IntramuralReview

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Sharon M Wahl. 2006-11-28. Transforming growth factor-beta: innately bipolar.. https://doi.org/10.1016/j.coi.2006.11.008

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