Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials.

Martin Prádný; Jirí Michálek; Petr Lesný; Ales Hejcl; Jirí Vacík; Miroslav Slouf; Eva Syková

doi:10.1007/s10856-006-0611-y

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PubMed · 17143768

Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials.

Martin Prádný·Jirí Michálek·Petr Lesný·Ales Hejcl·Jirí Vacík·Miroslav Slouf·Eva Syková

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Abstract

Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.

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Absorbable Implants Animals Biocompatible Materials Female Hydrogels Hydrolysis Materials Testing Methacrylates Porosity Rats Rats, Wistar Spinal Cord Diseases Journal Article Research Support, Non-U.S. Gov't

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Martin Prádný, Jirí Michálek, Petr Lesný, Ales Hejcl, Jirí Vacík, Miroslav Slouf, Eva Syková. 2006. Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials.. https://doi.org/10.1007/s10856-006-0611-y

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