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PubMed · 17150695

Schiff base-mediated base pairing.

Chikara Dohno·Akimitsu Okamoto·Isao Saito
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Abstract

We here present a novel covalently linked base pair via Schiff base formation between 5-formyluracil (fU) and 5-aminocytosine (AmC). The formation of Schiff base remarkably increases thermal stability of the duplex DNA, whereas it completely dissociates upon heating at 90 degrees C. Neither AmC nor fU produces covalent linkage with other natural bases, and thus the pairing ability of AmC and fU is very specific.

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Base PairingCytosineNucleic Acid DenaturationSchiff BasesTemperatureUracilJournal Article

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Chikara Dohno, Akimitsu Okamoto, Isao Saito. 2005. Schiff base-mediated base pairing.. https://doi.org/10.1093/nass%2F49.1.185

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