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PubMed · 17156897

Cyclopentanone ring-cleaved pleuromutilin derivatives.

Dane M Springer·Amy Bunker·Bing-Yu Luh·Margaret E Sorenson·Jason T Goodrich·Joanne J Bronson·Kenneth DenBleyker·Thomas J Dougherty·Joan Fung-Tomc
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Abstract

Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs<or=4 microg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.

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Anti-Bacterial AgentsDiterpenesMicrobial Sensitivity TestsPolycyclic CompoundsStaphylococcus aureusStreptococcus pneumoniaeStructure-Activity RelationshipPleuromutilinsJournal Article

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Dane M Springer, Amy Bunker, Bing-Yu Luh, Margaret E Sorenson, Jason T Goodrich, Joanne J Bronson, Kenneth DenBleyker, Thomas J Dougherty, Joan Fung-Tomc. 2006-12-06. Cyclopentanone ring-cleaved pleuromutilin derivatives.. https://doi.org/10.1016/j.ejmech.2006.07.018

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