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PubMed · 17158571

Multi-nanopore force spectroscopy for DNA analysis.

Carolina Tropini·Andre Marziali
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Abstract

The need for low-cost DNA sequence detection in clinical applications is driving development of new technologies. We demonstrate a method for detection of mutations in a DNA sequence purely by electronic means, and without need for fluorescent labeling. Our method uses an array of nanopores to perform synchronized single-molecule force spectroscopy measurements over many molecules in parallel, yielding detailed information on the kinetics of hundreds of molecule dissociations in a single measurement.

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MutationNanotechnologyOligonucleotidesPoly ASpectrum AnalysisJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Carolina Tropini, Andre Marziali. 2006-12-08. Multi-nanopore force spectroscopy for DNA analysis.. https://doi.org/10.1529/biophysj.106.094060

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