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PubMed · 17161301

Guinea pigs in hypersensitivity testing.

Thomas Maurer
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Abstract

The aim of the present paper is to mention steps of development of predictive guinea pig animal models for contact sensitization evaluation in parallel with the development of understanding the mechanism of contact sensitization. The guinea pigs methods are reviewed and the presently accepted methods (Buehler test, Maximization test) are discussed in details. Influences on the outcome of guinea pig sensitization assays are mentioned too. The predictability of the guinea pig methods is compared with predictive methods in mice, with human tests (human repeated insult patch test, HRIPT) and epidemiological data. In the last part, a testing strategy and steps for risk assessment of contact sensitizing potential is proposed.

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AnimalsDisease Models, AnimalGuinea PigsHumansHypersensitivityMicePatch TestsRisk AssessmentToxicity TestsJournal ArticleReview

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BibTeXRIS

Thomas Maurer. 2007. Guinea pigs in hypersensitivity testing.. https://doi.org/10.1016/j.ymeth.2006.06.017

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