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PubMed · 17163634

Stopping trouble before it starts.

Jon Clardy
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Abstract

A recent publication revealing that the cytotoxic marine natural product pateamine A targets eukaryotic initiation factor eIF4A continues a story with lessons for both chemists and biologists, that is, the significance of natural products, the importance of synthetic organic chemistry, the small molecule regulation of eukaryotic translation machinery, and possibly a new approach to cancer chemotherapy.

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Antineoplastic AgentsEpoxy CompoundsEukaryotic Initiation Factor-4AMacrolidesModels, GeneticModels, MolecularProtein BiosynthesisRNA, MessengerThiazolesJournal Article

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Jon Clardy. 2006-02-17. Stopping trouble before it starts.. https://doi.org/10.1021/cb0600029

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