Linking genome structure and function through specific histone acetylation.

Jeffrey C Hansen

doi:10.1021/cb6000894

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Linking genome structure and function through specific histone acetylation.

Jeffrey C Hansen

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Abstract

A recent publication shows that a simple chemical event, acetylation of lysine 16 on the histone H4 N-terminal tail domain (NTD), completely abolishes the ability of the H4 NTD to mediate the nucleosome-nucleosome interactions involved in chromatin condensation. This result provides novel insight into the molecular mechanism of histone acetylation and also implicates H4 K16acet-dependent changes in chromatin fiber architecture as a central mechanism for generating transcriptionally active genomic domains.

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Acetylation Histones Protein Structure, Tertiary Journal Article Review

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Jeffrey C Hansen. 2006-03-17. Linking genome structure and function through specific histone acetylation.. https://doi.org/10.1021/cb6000894

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