Errors in translation cause selective neurodegeneration.

Jean-Christophe Rochet

doi:10.1021/cb6004068

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PubMed · 17168550

Errors in translation cause selective neurodegeneration.

Jean-Christophe Rochet

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Abstract

The 3D structure of a protein is determined by the unique sequence of amino acid residues comprising the polypeptide chain. Sequence changes can cause protein misfolding, a potentially toxic phenomenon implicated in various neurodegenerative disorders. In a recent paper, translational misincorporation is proposed to be a new biochemical mechanism for generating mutant proteins that misfold and kill neurons.

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Animals Humans Models, Biological Models, Chemical Neurodegenerative Diseases Neurons Phenotype Protein Biosynthesis Protein Conformation Protein Denaturation Protein Folding Journal Article Review

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Jean-Christophe Rochet. 2006-10-24. Errors in translation cause selective neurodegeneration.. https://doi.org/10.1021/cb6004068

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