Desensitization at the interface.

James R Howe

doi:10.1021/cb6004382

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PubMed · 17168566

Desensitization at the interface.

James R Howe

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Abstract

Normal brain function requires the faithful transmission and integration of information on a timescale of milliseconds, and this rapid signaling is mediated by cell membrane receptors that are ligand-gated ion channels. Fast excitatory transmission occurs when synaptically released glutamate opens channels in neighboring neurons, but these channels desensitize rapidly during sustained high-frequency firing. Recent structural data have begun to provide important insights into the molecular mechanisms that underlie channel activation and desensitization.

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Animals Brain Calcium Channels Cell Membrane Humans Ion Channel Gating Models, Biological Models, Chemical Models, Molecular Neurons Receptors, Neurotransmitter Synaptic Transmission Journal Article Review

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James R Howe. 2006-11-21. Desensitization at the interface.. https://doi.org/10.1021/cb6004382

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