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PubMed · 1716952

c-src structure in human cancers with elevated pp60c-src activity.

P Wang·F Fromowitz·M Koslow·N Hagag·B Johnson·M Viola
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Abstract

We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types.

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Base SequenceCodonGenes, srcHumansMolecular Sequence DataMutagenesis, Site-DirectedMutationNeoplasmsOligodeoxyribonucleotidesPolymorphism, Restriction Fragment LengthProtein-Tyrosine KinasesProto-Oncogene Proteins pp60(c-src)RNA, MessengerJournal Article

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P Wang, F Fromowitz, M Koslow, N Hagag, B Johnson, M Viola. 1991. c-src structure in human cancers with elevated pp60c-src activity.. https://doi.org/10.1038/bjc.1991.344

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