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Lung carcinomas decrease the number of monocytes/macrophages (CD14+ cells) that produce TNF-alpha.

Jose Sullivan Lopez-Gonzalez·Federico Avila-Moreno·Heriberto Prado-Garcia·Dolores Aguilar-Cazares·Juan Jose Mandoki·Manuel Meneses-Flores
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Abstract

The role that inflammation plays in cancer is puzzling. In peripheral blood, TNF-alpha-producing monocytes (CD14+ cells) were compared among patients with lung cancer, patients with tuberculosis and healthy donors; also, in pleural effusion TNF-alpha-producing CD14+ cells were compared between tuberculous patients and lung cancer patients. To analyze the level of the cellular alteration in TNF-alpha production, an experimental model was set up. TNF-alpha-producing CD14+ cells in peripheral blood from lung cancer patients were significantly lower than those from healthy donors. In pleural effusion, TNF-alpha-producing CD14+ cells were significantly lower in lung cancer patients than in tuberculous patients. Based on the results obtained from an experimental model, we suggest that this phenomenon was attributed to a reduced expression of TNF-alpha transcript. These findings provide evidence that lung carcinomas reduce TNF-alpha production by macrophages, possibly by inducing in these cells an M2 phenotype, which favor tumor progression.

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AdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCell CommunicationCell CountCoculture TechniquesFemaleHumansImmunophenotypingLipopolysaccharide ReceptorsLung NeoplasmsMacrophagesMaleMiddle AgedTumor Necrosis Factor-alphaU937 CellsComparative StudyJournal Article

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Jose Sullivan Lopez-Gonzalez, Federico Avila-Moreno, Heriberto Prado-Garcia, Dolores Aguilar-Cazares, Juan Jose Mandoki, Manuel Meneses-Flores. 2006-12-18. Lung carcinomas decrease the number of monocytes/macrophages (CD14+ cells) that produce TNF-alpha.. https://doi.org/10.1016/j.clim.2006.11.003

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