Integrating cell-signalling pathways with NF-kappaB and IKK function.

Neil D Perkins

doi:10.1038/nrm2083

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Integrating cell-signalling pathways with NF-kappaB and IKK function.

Neil D Perkins

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Abstract

Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate.

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Animals Enzyme Activation Humans I-kappa B Kinase I-kappa B Proteins NF-kappa B Protein Subunits Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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Neil D Perkins. 2007. Integrating cell-signalling pathways with NF-kappaB and IKK function.. https://doi.org/10.1038/nrm2083

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