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Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences.

J G Guillet·J Hoebeke·R Lengagne·K Tate·F Borras-Herrera·A D Strosberg·F Borras-Cuesta
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Abstract

We present a homology scanning microcomputer program to predict functional T-cell epitopes within proteins. By taking into account particular human or mouse restriction elements the predictions are made haplotype-specific. The generality of this approach is confirmed by (i) identification of well-characterized immunogenic T-cell determinants in lysozyme (ii) search for potential T epitopes on unanalysed proteins like the human beta 2-adrenoreceptor (iii) modification of non-immunogenic peptide sequences in order to generate T-cell determinants.

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AlgorithmsAmino Acid SequenceAnimalsCells, CulturedEgg WhiteEpitopesHaplotypesMiceMice, Inbred BALB CMice, Inbred CBAMicrocomputersMolecular Sequence DataMuramidaseReceptors, Adrenergic, betaSequence Homology, Nucleic AcidT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov't

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J G Guillet, J Hoebeke, R Lengagne, K Tate, F Borras-Herrera, A D Strosberg, F Borras-Cuesta. 1991. Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences.. https://doi.org/10.1002/jmr.300040104

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