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PubMed · 17189424

Microinversions in mammalian evolution.

M J Chaisson·B J Raphael·P A Pevzner
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Abstract

We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phylogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.

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AnimalsBiological EvolutionComputational BiologyGenetic VectorsHumansMammalsJournal ArticleResearch Support, N.I.H., IntramuralResearch Support, Non-U.S. Gov't

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M J Chaisson, B J Raphael, P A Pevzner. 2006-12-22. Microinversions in mammalian evolution.. https://doi.org/10.1073/pnas.0603984103

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