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Chemical genetics: an evolving toolbox for target identification and lead optimization.

Helena I Boshoff·Cynthia S Dowd
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Abstract

Chemical genetics combines chemistry with biology as a means of exploring the function of unknown proteins or identifying the proteins responsible for a particular phenotype. Chemical genetics is thus a valuable tool in the identification of novel drug targets. This chapter describes the application of chemical genetics in traditional and systems-based approaches to drug target discovery and the tools/approaches that appear most promising for guiding future pharmaceutical development.

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Combinatorial Chemistry TechniquesDrug DesignGeneticsGenomicsMagnetic Resonance SpectroscopyMass SpectrometryPhenotypeProtein BindingProteinsSystems BiologyTranscription, GeneticJournal ArticleReview

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Helena I Boshoff, Cynthia S Dowd. 2007. Chemical genetics: an evolving toolbox for target identification and lead optimization.. https://doi.org/10.1007/978-3-7643-7567-6_3

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