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Defining an epigenetic code.

Bryan M Turner
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Abstract

The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.

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AnimalsChromatinEpigenesis, GeneticGene Expression Regulation, DevelopmentalHistonesMethylationModels, GeneticNucleosomesTranscription, GeneticJournal Article

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Bryan M Turner. 2007. Defining an epigenetic code.. https://doi.org/10.1038/ncb0107-2

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