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PubMed · 17202851

SUMOylation code in cancer development and metastasis.

Keun Il Kim·Sung Hee Baek
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Abstract

Protein modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of protein targets including transcription factors and coregulators mainly in the nucleus and participates in maintaining cellular homeostasis. In addition, SUMO system plays important roles in DNA damage repair and maintaining genome integrity. Thus, in some cases, the loss of control on SUMOylation or deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development. Furthermore, recent study showed that SUMO system is also involved in cancer metastasis. In this review, we will summarize and discuss the possible role of SUMO system in cancer development and metastasis.

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AnimalsGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisNeoplasmsProtein Processing, Post-TranslationalSmall Ubiquitin-Related Modifier ProteinsTumor Suppressor Protein p53Journal ArticleResearch Support, Non-U.S. Gov'tReview

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Keun Il Kim, Sung Hee Baek. 2006-12-31. SUMOylation code in cancer development and metastasis.. https://pubmed.ncbi.nlm.nih.gov/17202851/

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