Probing the structure and function of the nuclear pore complex.

C W Akey

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PubMed · 1720335

Probing the structure and function of the nuclear pore complex.

C W Akey

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Abstract

Nucleocytoplasmic transport is a bi-directional process mediated by the nuclear pore complex (NPC), which results in a segregation of cytoplasmic and nuclear macromolecules within cells. Some progress has been made in understanding the mechanistic basis of this selective transport phenomenon. In particular, cryo-electron microscopy of frozen-hydrated nuclear envelopes coupled with image processing and labeling studies, has provided a glimpse of the transporter at the center of the NPC.

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Amino Acid Sequence Animals Biological Transport Cryoultramicrotomy Image Enhancement Microscopy, Electron Models, Biological Molecular Sequence Data Necturus Nuclear Envelope Staining and Labeling Xenopus Journal Article Research Support, U.S. Gov't, P.H.S.Review

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C W Akey. 1991. Probing the structure and function of the nuclear pore complex.. https://pubmed.ncbi.nlm.nih.gov/1720335/

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