Gene trap mutagenesis.

A Abuin; G M Hansen; B Zambrowicz

doi:10.1007/978-3-540-35109-2_6

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PubMed · 17203654

Gene trap mutagenesis.

A Abuin·G M Hansen·B Zambrowicz

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Abstract

Our ability to genetically manipulate the mouse has had a great impact on medical research over the last few decades. Mouse genetics has developed into a powerful tool for dissecting the genetic causes of human disease and identifying potential targets for pharmaceutical intervention. With the recent sequencing of the human and mouse genomes, a large number of novel genes have been identified whose function in normal and disease physiology remains largely unknown. Government-sponsored multinational efforts are underway to analyze the function of all mouse genes through mutagenesis and phenotyping, making the mouse the interpreter of the human genome. A number of technologies are available for the generation of mutant mice, including gene targeting, gene trapping and transposon, chemical or radiation-induced mutagenesis. In this chapter, we review the current status of gene trapping technology, including its applicability to conditional mutagenesis.

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Alleles Animals Gene Targeting Genotype Humans Mutagenesis Mutation Journal Article Review

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A Abuin, G M Hansen, B Zambrowicz. 2007. Gene trap mutagenesis.. https://doi.org/10.1007/978-3-540-35109-2_6

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