Autophagy regulates ageing in C. elegans.

Eszter S Hars; Haiyan Qi; Alexey G Ryazanov; Shengkan Jin; Li Cai; Chengcheng Hu; Leroy F Liu

doi:10.4161/auto.3636

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Autophagy regulates ageing in C. elegans.

Eszter S Hars·Haiyan Qi·Alexey G Ryazanov·Shengkan Jin·Li Cai·Chengcheng Hu·Leroy F Liu

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Abstract

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

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Aging Animals Autophagy Caenorhabditis elegans Caenorhabditis elegans Proteins Longevity Proportional Hazards Models RNA Interference Survival Analysis Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Eszter S Hars, Haiyan Qi, Alexey G Ryazanov, Shengkan Jin, Li Cai, Chengcheng Hu, Leroy F Liu. 2007-03-30. Autophagy regulates ageing in C. elegans.. https://doi.org/10.4161/auto.3636

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