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PubMed · 17209353

[How estrogens will surprise us again?].

Izabela Malinowska-Kołodziej·Wiesław Marcol·Joanna Lewin-Kowalik
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Abstract

Estrogens are pleiotropic hormones having an influence not only on reproductive system and sexual functions. These hormones are synthesized not only by ovaries, but also by glia in central nervous system (CNS) and Schwann cells in peripheral nervous system. Therefore they create microenvironment having a wide spectrum of effects such as neuroprotective and antiapoptotic or supporting neurogenesis and regeneration. Mechanisms of estrogens activity are both genomic and quick non-genomic transmitted through second intracellular messengers. There is evidence for protective action of estrogens in neurodegenerative diseases and other diseases of CNS. Nevertheless there are still secrets in estrogens nature. This fact pushes us to ask more questions and continue scientific research to look for the answer.

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Alzheimer DiseaseAnimalsCentral Nervous SystemEstradiolEstrogensFemaleFertilityGene Expression Regulation, EnzymologicHumansMaleMood DisordersNeurodegenerative DiseasesNeuronsNeuroprotective AgentsPhytoestrogensRatsReceptors, EstrogenEnglish AbstractJournal ArticleReview

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Izabela Malinowska-Kołodziej, Wiesław Marcol, Joanna Lewin-Kowalik. 2006. [How estrogens will surprise us again?].. https://pubmed.ncbi.nlm.nih.gov/17209353/

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