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Simple proteomic checks for detecting noncoding RNA.

Stéphane Cruveiller·Oliver Clay·Kamel Jabbari·Giorgio Bernardi
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Abstract

Proper validation can accelerate sequence-based discovery of proteins and protein-coding genes. Databases currently contain a backlog of experimentally unverified gene models and tentative assignments of observed transcripts to coding or noncoding RNA. We present and apply a general principle, founded on base composition and the genetic code and validated here by bulk 2-D gels, that can improve the reliability of such classifications and of the algorithms or pipelines that lead to them.

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Base CompositionElectrophoresis, Gel, Two-DimensionalIsoelectric PointProteomicsRNA, UntranslatedJournal Article

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Stéphane Cruveiller, Oliver Clay, Kamel Jabbari, Giorgio Bernardi. 2007. Simple proteomic checks for detecting noncoding RNA.. https://doi.org/10.1002/pmic.200600813

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Base Composition↗
PubMed2007

Application of CE for determination of DNA base composition.

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