PubMed · 17214879
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Klaus Kayser. 2007-01-10. Diagnostic pathology - editorial.. https://doi.org/10.1186/1746-1596-2-2
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.