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PubMed · 17216403

Generalized, switch-like competitive heterodimerization networks.

Olivier Cinquin·Karen M Page
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Abstract

High-dimensional switches have been proposed as a way to model cellular differentiation, particularly in the context of basic Helix-Loop-Helix (bHLH) competitive heterodimerization networks. A previous study derived a simple rule showing how many elements can be co-expressed, depending on the rate of competition within the network. A limitation to that rule, however, is that many biochemical parameters were considered to be identical. Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extracellular cues.

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Basic Helix-Loop-Helix ProteinsCell DifferentiationModels, BiologicalSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov't

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Olivier Cinquin, Karen M Page. 2007-01-11. Generalized, switch-like competitive heterodimerization networks.. https://doi.org/10.1007/s11538-006-9114-8

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