Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.

A S Pivovarov; E I Drozdova; B I Kotlyar

doi:10.1007/bf01191567

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Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.

A S Pivovarov·E I Drozdova·B I Kotlyar

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Abstract

A reversible decrease in the rate and depth of the extinction of the reactions of the cholinoreceptive membrane to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockers was demonstrated in identified RPa3 and LPa3 neurons in the edible snail using the method of recording transmembrane ionic currents: R 24571 (20-50 mumols/liter), trifluoperazine (50-200 mumols/liter), chlorpromazine (20-60 mumols/liter), and prenylamine lactate (30-400 mumols/liter). The results obtained attest to the positive regulation of short-term plasticity of the cholinoreceptors of the neurons in question by calmodulin.

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Acetylcholine Animals Calmodulin Chlorpromazine Dimethyl Sulfoxide Electric Stimulation Helix, Snails Imidazoles Ion Channels Lactates Membrane Potentials Neurons Prenylamine Receptors, Cholinergic Trifluoperazine Journal Article

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A S Pivovarov, E I Drozdova, B I Kotlyar. Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.. https://doi.org/10.1007/bf01191567

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