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DNA and RNA within the nucleus: how much sequence-specific spatial organization?

K C Carter·J B Lawrence
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Abstract

Spatial organization of various nuclear components is often proposed as a means by which nuclei more efficiently carry out their various tasks. Such functional compartmentalization may involve a sequence-specific packaging and placement of DNA and RNA. Here we review recent insights, allowed primarily by advances in fluorescent in situ hybridization methodology, into the organization of nucleic acids within individual nuclei.

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Cell CycleChromatinDNAFluorescent Antibody TechniqueHumansNucleic Acid HybridizationRNAJournal ArticleReview

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K C Carter, J B Lawrence. 1991. DNA and RNA within the nucleus: how much sequence-specific spatial organization?. https://doi.org/10.1002/jcb.240470205

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