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Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane.

Ian J Russell·P Kevin Legan·Victoria A Lukashkina·Andrei N Lukashkin·Richard J Goodyear·Guy P Richardson
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Abstract

Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular matrix that overlies the cochlea's sensory epithelium. The tectorial membrane contains radially organized collagen fibrils that are imbedded in an unusual striated-sheet matrix formed by two glycoproteins, alpha-tectorin (Tecta) and beta-tectorin (Tectb). In Tectb(-/-) mice the structure of the striated-sheet matrix is disrupted. Although these mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantly enhanced in the high-frequency regions of the cochlea, with little loss in sensitivity. These findings can be attributed to a reduction in the acting mass of the tectorial membrane and reveal a new function for this structure in controlling interactions along the cochlea.

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AnimalsBasilar MembraneCells, CulturedChimeraCochleaCollagenExtracellular MatrixExtracellular Matrix ProteinsGPI-Linked ProteinsHair Cells, Auditory, OuterHearingHearing Loss, SensorineuralMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMutationPitch PerceptionTectorial MembraneJournal ArticleResearch Support, Non-U.S. Gov't

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Ian J Russell, P Kevin Legan, Victoria A Lukashkina, Andrei N Lukashkin, Richard J Goodyear, Guy P Richardson. 2007-01-14. Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane.. https://doi.org/10.1038/nn1828

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