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Bone formation after sinus augmentation with engineered bone.

Christoph Zizelmann·Ralf Schoen·Marc Christian Metzger·Rainer Schmelzeisen·Alexander Schramm·Britta Dott·Kai-Hendrik Bormann·Nils Claudius Gellrich
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Abstract

OBJECTIVES: The aim of the following investigation was to quantify the resorption rate of tissue-engineered bone grafts in the maxillary sinus using volume measurements. MATERIAL AND METHODS: Sinus floor augmentation using autologous bone grafts from the iliac crest (n=17, group 1) was compared with commercially produced transplants of human cells seeded on polyglycolid-polylactid (PLGA) scaffolds (Oral Bone) (n=14, group 2). RESULTS: The total resorption rate for autologous transplants 3 months post operation was 29%, while the tissue-engineered bone showed a resorption rate of 90%. The autologous bone had a bone density of up to 266-551 Hounsfield units (HU), while sufficient mineralization of tissue-engineered bone was found in only one case (152 HU). CONCLUSION: In this clinical study, the use of autologous cancellous bone grafts in sinus augmentation was more reliable than scaffolds containing cultured osteoblasts. Further tissue-engineered bone transplants should be examined to draw general conclusions about the use of tissue-engineered grafts compared with autologous bone grafts for maxillary sinus augmentation.

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Alveolar Ridge AugmentationBiocompatible MaterialsBone DensityBone ResorptionBone TransplantationDental Implantation, EndosseousDental ImplantsFollow-Up StudiesHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLactic AcidMaxillaMaxillary SinusOsteoblastsOsteogenesisPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersTissue EngineeringTomography, X-Ray ComputedTransplantation, AutologousComparative StudyJournal Article

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Christoph Zizelmann, Ralf Schoen, Marc Christian Metzger, Rainer Schmelzeisen, Alexander Schramm, Britta Dott, Kai-Hendrik Bormann, Nils Claudius Gellrich. 2007. Bone formation after sinus augmentation with engineered bone.. https://doi.org/10.1111/j.1600-0501.2006.01295.x

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