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PubMed · 17224650

p63, cellular senescence and tumor development.

Xuecui Guo·Alea A Mills
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Abstract

Deficiency of p63, a p53-related protein, causes severe defects in epithelial morphogenesis. Studies of p63-compromised mouse models reveal that p63 deficiency induces cellular senescence both in cultured cells and in vivo, through regulation p19(Arf)/p53 and p16(Ink4a)/Rb pathways. An extensive tumor study of p63-compromised mice demonstrated that p63 deficiency does not predispose to, but rather protects from, tumor development. These findings further implicate p63 as a negative regulator of the tumor suppressive mechanism of cellular senescence.

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AnimalsCellular SenescenceDNA-Binding ProteinsHumansModels, BiologicalNeoplasmsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsJournal ArticleReview

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Xuecui Guo, Alea A Mills. 2007-02-03. p63, cellular senescence and tumor development.. https://doi.org/10.4161/cc.6.3.3794

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