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PubMed · 172950

Experimental immunosuppression induced by herpes simplex virus.

R Cappel·C Henry·L Thiry
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Abstract

Cell-mediated immune response was studied in experimental herpetic infection in mice. Our data suggest that herpes simplex virus induced immunosuppression in mice. This depression was documented by the unresponsiveness of the lymphocytes to PHA stimulation in vitro and by the enhanced susceptibility of adult mice to Coxsackie B virus infection. Our data also suggest that levamisole, a potent immunostimulant drug, had no effect on the unresponsiveness of the lymphocytes to PHA stimulation.

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AnimalsAntibodies, ViralAntibody FormationCoxsackievirus InfectionsCytotoxicity Tests, ImmunologicDisease Models, AnimalEnterovirusHerpes SimplexImmunosuppression TherapyInjections, SubcutaneousLectinsLevamisoleLymphocyte ActivationLymphocytesMiceSimplexvirusJournal Article

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R Cappel, C Henry, L Thiry. 1975. Experimental immunosuppression induced by herpes simplex virus.. https://doi.org/10.1007/bf02175597

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