Thymic nurse cell lymphocytes react against self major histocompatibility complex.

J Penninger; G Wick

doi:10.1002/eji.1830220113

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Thymic nurse cell lymphocytes react against self major histocompatibility complex.

J Penninger·G Wick

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Abstract

It has been postulated that thymic nurse cells (TNC), lymphoid-epithelial complexes composed of thymocytes enclosed within major histocompatibility complex (MHC) class I+ and class II+ cortical epithelial cells, may provide an optimal microenvironment for the process of T cell selection. By transplanting single TNC in the avian chorionallantoic membrane assay we demonstrate that a significant portion of intra-TNC lymphocytes (TNC-L) possess reactivity against self-MHC molecules. The frequency of these autoreactive cells among TNC-L exceeds by far that of thymocytes or peripheral blood lymphocytes of the same donor. These results indicate that TNC-L constitute a T cell population enriched for self-MHC reactivity, i.e. cells that have undergone positive selection, but not yet deletion and/or deactivation.

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Animals Autoantigens Chickens Female Graft vs Host Reaction Histocompatibility Antigens Male Receptors, Antigen, T-Cell T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't

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J Penninger, G Wick. 1992. Thymic nurse cell lymphocytes react against self major histocompatibility complex.. https://doi.org/10.1002/eji.1830220113

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