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PubMed · 1732163

Pleiotropy and multilocus polymorphisms.

A Gimelfarb
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Abstract

It is demonstrated that systems of two pleiotropically related characters controlled by additive diallelic loci can maintain under Gaussian stabilizing selection a stable polymorphism in more than two loci. It is also shown that such systems may have multiple stable polymorphic equilibria. Stabilizing selection generates negative linkage disequilibrium, as a result of which the equilibrium phenotypic variances are quite low, even though the level of allelic polymorphisms can be very high. Consequently, large amounts of additive genetic variation can be hidden in populations at equilibrium under stabilizing selection on pleiotropically related characters.

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Genetic LinkageGenetic VariationMathematicsModels, GeneticNormal DistributionPhenotypePolymorphism, GeneticSelection, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A Gimelfarb. 1992. Pleiotropy and multilocus polymorphisms.. https://doi.org/10.1093/genetics%2F130.1.223

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