Structural differences between the two human complement C4 isotypes affect the humoral immune response.

O Finco; S Li; M Cuccia; F S Rosen; M C Carroll

doi:10.1084/jem.175.2.537

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Structural differences between the two human complement C4 isotypes affect the humoral immune response.

O Finco·S Li·M Cuccia·F S Rosen·M C Carroll

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Abstract

An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not.

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Animals Antibody Formation Bacteriophages Complement C4a Complement C4b Disease Models, Animal Escherichia coli Guinea Pigs Humans Immunoglobulin G Immunoglobulin Isotypes Immunoglobulin M Immunoglobulin Switch Region Male Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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O Finco, S Li, M Cuccia, F S Rosen, M C Carroll. 1992-02-01. Structural differences between the two human complement C4 isotypes affect the humoral immune response.. https://doi.org/10.1084/jem.175.2.537

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