PubMed · 1741004
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B Noerr. 1992. Chloral hydrate.. https://pubmed.ncbi.nlm.nih.gov/1741004/
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The decomposed products of trichlorfon in gas chromatographic analysis were identified by mass spectrometry (MS). After MS interpretation, three decomposed products, trichloroacetaldehyde, dimethyl phosphite and dichlorvos were identified. The effects of gas chromatographic conditions on decomposed products of trichlorfon, e. g. injection temperature, injection mode and oven ramp, were studied. The experiments showed that all of the factors have effects on decomposed products of trichlorfon, however, the injection temperature is the key factor to cause trichlorfon being decomposed. The higher the injection temperature is, the bigger the amount of trichlorfon being decomposed. When the injection temperature was raised from 150 degrees C to 250 degrees C, the remaining trichlorfon fell from 86% to 20%. Therefore, on-cold column injection mode gas chromatography or high performance liquid chromatography was recommended for exact quantification of trace trichlorfon.
Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of process impurities in which the atoms of chloral (Cl3CCHO) are incorporated between the 5'-oxygen and phosphorus atoms of an internucleotide linkage. The structure was elucidated by HPLC with UV and MS detection, digestion of the oligonucleotide, synthesis of model compounds, and 1H and 31P NMR spectroscopy. By understanding the chemistry behind its formation, we are now able to limit levels of this impurity in synthetic oligonucleotides by limiting chloral in DCA.
Results of ABR examination in infants undergone the hearing screening examinations were presented. Since February 2004 the group of 184 children were examined. In 29 of them (15.8%) there was a need of further hearing examination using evoked auditory brainstem responses. In 20 of them the examination was done in sleep induced by 6% chloral hydrate enema. The process of sleep was normal and no disturbances of breathing or circulatory systems were observed. The obtained responses from brainstem were not interfered by any artifacts and basic waves were legible and easy for interpretation. Correct results of the ABR examination were obtained in 21/29 (72%) children, while in 7/28 (24%) various degree of hearing losses were detected. Those children were referred for hearing rehabilitation to the Third Degree of Reference Center. It was emphasized in the study that results of ABR examination after conscious sedation induced by 6% chloral hydrate enema accounted the suggestion for its wider use in other clinical and hospital center.