Computation of frequency-to-spatial transform by olfactory bulb glomeruli.

P S Antón; G Lynch; R Granger

doi:10.1007/bf00216975

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Computation of frequency-to-spatial transform by olfactory bulb glomeruli.

P S Antón·G Lynch·R Granger

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Abstract

A physiological simulation of 2.5% of the input and inhibitory neurons and 25% of the primary mitral/tufted cells in a single mammalian olfactory bulb glomerulus was constructed. This physiological simulation used the integrate-and-fire paradigm with realistic activation curves and synaptic delays. The dendritic integration incorporated non-linear interactive effects of individual cell excitatory and inhibitory post-synaptic potentials (PSPs) from both axodendritic and dendro-dendritic synaptic contacts. Refractory periods for granule-cell inhibition of mitral/tufted cell activity lead to relatively fixed-frequency rhythmic activity in the glomerulus, independent of the input frequency from the olfactory nerve. Though the frequency of mitral/tufted cell firing in bulb was approximately independent of input frequency, the number of cells active in the glomerulus was a roughly-linear function of input frequency to the glomerulus, indicating the mechanism's ability to function as a frequency-to-spatial encoder.

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Animals Evoked Potentials Mammals Mathematics Models, Neurological Neurons Odorants Olfactory Bulb Olfactory Nerve Synapses Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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P S Antón, G Lynch, R Granger. 1991. Computation of frequency-to-spatial transform by olfactory bulb glomeruli.. https://doi.org/10.1007/bf00216975

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