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PubMed · 1747829

Antimicrobial prophylaxis in general surgery.

J M Bohnen
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Abstract

When used appropriately, antimicrobial prophylaxis is highly beneficial and cost effective. Antibiotics are not indicated for "clean procedures" such as hernia and breast surgery. A single preoperative dose will suffice, followed by an intraoperative dose if the operation takes more than 3 hours. For vascular (prosthesis or groin wound), head and neck (pharynx entered), thoracic (gastrointestinal or respiratory entrance) and high-risk gastroduodenal and biliary procedures, cefazolin, 1 g intravenously, is indicated. For procedures involving small intestine, appendix or penetrating abdominal trauma, cefoxitin or cefotetan, 2 g intravenously, is indicated. For colorectal procedures, either oral neomycin plus erythromycin or intravenous aminoglycoside plus clindamycin (or metronidazole) are effective. If valvular heart disease is present, endocarditis prophylaxis should be administered.

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Anti-Bacterial AgentsBacterial InfectionsHumansPremedicationSurgical Procedures, OperativeJournal ArticleReview

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J M Bohnen. 1991. Antimicrobial prophylaxis in general surgery.. https://pubmed.ncbi.nlm.nih.gov/1747829/

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