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PubMed · 1748353

Isomeric amphetamines--a problem for urinalysis?

F P Smith·D A Kidwell
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Abstract

Alkyl amphetamine isomers (amphetamine, 1-phenyl-2-butylamine (PBA), methamphetamine, N-methyl-PBA, N,N-dimethylamphetamine, N-ethylamphetamine, N-ethyl-PBA and N,N-diethylamphetamine) were purchased or synthesized and tested by immunoassay and GC/MS for their detectability in urine. Some cross reactivity was observed with PBA, N-methyl-PBA N-ethylamphetamine, and N-ethyl-PBA when analyzed using a series of commercial amphetamine and methamphetamine immunoassays. Chromatographic co-elution problems were observed for the underivatized isomeric group N,N-dimethylamphetamine, N-ethylamphetamine, and N-methyl-PBA under GC/MS conditions used; and their GC/MS spectra were quite similar. Of the potential derivatives, pentafluoropropionyl (PFP) anhydride and heptafluorobutyryl (HFB) anhydride provided adequate separation and easily distinguishable spectra using the electron-impact GC/MS conditions specified.

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AmphetaminesCross ReactionsGas Chromatography-Mass SpectrometryHumansImmunoassayImmunoenzyme TechniquesIsomerismMethamphetamineRadioimmunoassaySubstance Abuse DetectionJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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BibTeXRIS

F P Smith, D A Kidwell. 1991. Isomeric amphetamines--a problem for urinalysis?. https://doi.org/10.1016/0379-0738(91)90147-b

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