The enkephalins and opiates: structure-activity relations.

A S Horn; J R Rodgers

doi:10.1111/j.2042-7158.1977.tb11308.x

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The enkephalins and opiates: structure-activity relations.

A S Horn·J R Rodgers

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Abstract

The X-ray structures of 9 "opiate" drugs which exhibit a range of pharmacological activity have been examined in detail leading to the theory that one of the reasons why the enkephalins and related peptides possess morphine-like activity is because they have a tyrosine, and hence a "tyramine", residue at the amino terminal position. This residue or a conformationally similar moiety, can be shown to be present in many opiates and analogues.

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Amino Acid Sequence Analgesics, Opioid Animals Chemical Phenomena Chemistry Enkephalins Humans In Vitro Techniques Molecular Conformation Narcotics Oligopeptides Peptides Receptors, Opioid Structure-Activity Relationship X-Ray Diffraction Journal Article

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A S Horn, J R Rodgers. 1977. The enkephalins and opiates: structure-activity relations.. https://doi.org/10.1111/j.2042-7158.1977.tb11308.x

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