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PubMed · 1772958

Platelets process adsorbed protein: a morphological study.

K Gaebel·I A Feuerstein
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Abstract

The nature of the adsorbed protein on a non-biological biomaterial surface is known to influence cell adhesion. This work deals with the contribution of adherent platelets towards the redistribution of preadsorbed proteins. A redistribution was only observed with spread platelets on adsorbed fibrinogen and fibronectin, but not with adsorbed beta-lactoglobulin. The labelled protein images showed a dark outer ring with an inner region having fluorescent areas, with greater intensity than regions not covered by platelets. The fluorescent patterns observed may be a result of the binding of adsorbed fluorescent protein to the glycoprotein IIb/IIIa receptors of platelets, followed by their redistribution within the plasma membrane.

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AdsorptionAdultBiocompatible MaterialsBlood PlateletsBlood ProteinsFibrinogenFibronectinsFluorescenceHumansLactoglobulinsMethylmethacrylatesMicroscopy, Electron, ScanningMolecular WeightPlatelet AdhesivenessJournal ArticleResearch Support, Non-U.S. Gov't

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K Gaebel, I A Feuerstein. 1991. Platelets process adsorbed protein: a morphological study.. https://doi.org/10.1016/0142-9612(91)90058-i

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