Echinococcus multilocularis antigens modify accessory cell function of macrophages.

N K Rakha; J B Dixon; S D Carter; P S Craig; P Jenkins; S Folkard

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PubMed · 1783424

Echinococcus multilocularis antigens modify accessory cell function of macrophages.

N K Rakha·J B Dixon·S D Carter·P S Craig·P Jenkins·S Folkard

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Abstract

Peritoneal macrophages and splenic lymphocytes were collected from BALB/c mice, normal or previously infected with Echinococcus multilocularis. In an accessory cell function assay, peritoneal macrophages, in increasing numbers, were added to cultures of splenic lymphocytes. Cultures were stimulated by concanavalin A (Con A) or E. multilocularis culture supernatant (EMSN). Post-infection macrophages, unlike normal macrophages, suppressed Con A- and EMSN-driven lymphocyte transformation. Modification of accessory cells could also be repeatedly induced in vivo by EMSN or a single FPLC fraction of EMSN. Lymphocytes were made more sensitive to accessory cell signals following incubation with EMSN.

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Animals Antigen-Presenting Cells Antigens, Helminth Concanavalin A Echinococcosis Echinococcus Immune Tolerance Lymphocyte Activation Macrophages Mice Mice, Inbred BALB C Peritoneal Cavity Journal Article

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N K Rakha, J B Dixon, S D Carter, P S Craig, P Jenkins, S Folkard. 1991. Echinococcus multilocularis antigens modify accessory cell function of macrophages.. https://pubmed.ncbi.nlm.nih.gov/1783424/

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