MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling.

O Giorgi; M Orlandi; M Geic; M G Corda

doi:10.1016/0361-9230(91)90218-9

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MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling.

O Giorgi·M Orlandi·M Geic·M G Corda

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Abstract

Chemical kindling was induced in the rat by chronic treatment with pentylenetetrazol (PTZ, 30 mg/kg, IP, three times a week for eight weeks). PTZ kindling was associated with a reduction in central GABAergic function, as reflected by a significant decrease in the density of 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding sites in the cerebral cortex. The pretreatment with the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (1 mg/kg, IP, 40 min before each PTZ injection) prevented the development of kindling as well as the reduction in 35S-TBPS binding. The results suggest that NMDA receptors may play a role in the alterations of GABAergic function observed in PTZ-kindled rats.

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Animals Bridged Bicyclo Compounds Bridged Bicyclo Compounds, Heterocyclic Cerebral Cortex Convulsants Disease Susceptibility Dizocilpine Maleate Kindling, Neurologic Male Pentylenetetrazole Rats Rats, Inbred Strains Seizures Sulfur Radioisotopes Journal Article

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O Giorgi, M Orlandi, M Geic, M G Corda. 1991. MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling.. https://doi.org/10.1016/0361-9230(91)90218-9

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