[Vitamin E and its structural analogs in tuberculosis].

A V Panasiuk; O R Penenko; I V Kuz'menko; E I Suslov; M T Klimenko; N I Kuznitsa; T A Tumanova; V P Makovetskiĭ; G V Donchenko

PubMed · 1788879

[Vitamin E and its structural analogs in tuberculosis].

A V Panasiuk·O R Penenko·I V Kuz'menko·E I Suslov·M T Klimenko·N I Kuznitsa·T A Tumanova·V P Makovetskiĭ·G V Donchenko

Abstract

Efficiency of tocopherol, its analog with a shortened side chain as well as their quinons for tuberculosis was determined. All the studied compounds inhibited peroxide-formation processes in the liver homogenate and mitochondria. The vitamin E amount in the blood is considerably decreased in case of tuberculosis. The studied analogs increased its content and possessed a weak tuberculostatic but expressed antiedemic and antiinflammatory action. Administration of vitamin E in combination with isoniazid to sick animals had a favourable effect on the processes of tissue respiration and oxidative phosphorylation. If taking a sum of characters, tocopherol acetate with a shortened side chain is the most efficient of all the analogs under study for the tuberculosis therapy.

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Animals Drug Therapy, Combination Guinea Pigs Isoniazid Liver Mitochondria, Liver Oxidative Phosphorylation Oxygen Consumption Quinones Tuberculosis, Pulmonary Vitamin E English Abstract Journal Article

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A V Panasiuk, O R Penenko, I V Kuz'menko, E I Suslov, M T Klimenko, N I Kuznitsa, T A Tumanova, V P Makovetskiĭ, G V Donchenko. [Vitamin E and its structural analogs in tuberculosis].. https://pubmed.ncbi.nlm.nih.gov/1788879/

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