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PubMed · 1794996

Water-curable and biodegradable prepolymers.

H Kobayashi·S H Hyon·Y Ikada
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Abstract

In an attempt to develop biodegradable polymers which can be shaped in situ and adhere to living tissues, we synthesized esterurethane prepolymers which can be cured upon contact with water in living tissues. First, D,L-lactide polymerization or D,L-lactide-epsilon-caprolactone (50:50) copolymerization was carried out using ethylene glycol or poly(ethylene glycol) as initiator to obtain hydroxyl-terminated biodegradable polyesters. They were then reacted with an excess of diisocyanate such as hexamethylene diisocyanate, toluylene diisocyanate, and diphenylmethane diisocyanate to introduce a reactive isocyanate group to both of the end groups of the polyesters. The isocyanate-terminated prepolymers could be cured in the presence of water and the cured polymers were degraded by hydrolysis both in vitro and in vivo. It was found that the presence of appropriate amounts of hydrophilic units in the main chain was essential for giving a high curing rate and a high degradation rate for the biodegradable urethane prepolymers. The tissue responses to the cured polymers were not severe.

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AnimalsBiocompatible MaterialsBiodegradation, EnvironmentalIndicators and ReagentsMaterials TestingMolecular WeightPolyestersPolyethylene GlycolsPolyurethanesRatsRats, Inbred StrainsTensile StrengthWaterJournal Article

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H Kobayashi, S H Hyon, Y Ikada. 1991. Water-curable and biodegradable prepolymers.. https://doi.org/10.1002/jbm.820251206

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