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PubMed · 1798730

[Polysaccharides from Nerium oleander: structure and biological activity].

B M Müller·F Rosskopf·D H Paper·J Kraus·G Franz
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Abstract

A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide. The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor activity did not result in a significant action. Investigation of immunomodulating activity brought some indications for mitogenic activity and a weak macrophage-mediated cytotoxicity. Increase of phagocytosis could not be doubtlessly assigned to the polysaccharide due to the high amount of endotoxin in the homogenous fraction OLE 2.

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AnimalsAntineoplastic Agents, PhytogenicCell SurvivalFemaleHydrolysisImmunologic FactorsIn Vitro TechniquesLimulus TestLymphocytesMacrophagesMagnetic Resonance SpectroscopyMaleMethylationMiceMice, Inbred C3HMitogensPhagocytosisPlant ExtractsPlants, MedicinalPolysaccharidesProtease InhibitorsStructure-Activity RelationshipTumor Cells, CulturedEnglish AbstractJournal Article

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B M Müller, F Rosskopf, D H Paper, J Kraus, G Franz. 1991. [Polysaccharides from Nerium oleander: structure and biological activity].. https://pubmed.ncbi.nlm.nih.gov/1798730/

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