B cell commitment.

C J Paige; A Cumano; G E Wu

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PubMed · 1799666

B cell commitment.

C J Paige·A Cumano·G E Wu

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Abstract

Multipotential stem cells have the capacity to differentiate into a variety of cell types including B lymphocytes. The development of B cells from multipotential progenitors has been the subject of numerous studies and many aspects of this transition are well characterized. However, the initial genetic events which commit a stem cell to follow the B lineage developmental pathway have not yet been discovered. In this review we examine diverse experiments which may lead to increased understanding of the important first steps in the commitment process.

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Animals B-Lymphocytes Cell Differentiation Genes, Immunoglobulin Hematopoietic Cell Growth Factors Hematopoietic Stem Cells Macrophages Mice Receptors, Colony-Stimulating Factor Journal Article Research Support, Non-U.S. Gov't Review

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C J Paige, A Cumano, G E Wu. 1991. B cell commitment.. https://pubmed.ncbi.nlm.nih.gov/1799666/

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